In book one, Chris, now Christina, and Chrissie to his/her friends had been labeled as a transgender boy to girl and found himself living and passing as a college co-ed and cheerleader.
In part 2, he gets injections of estrogen. He didn't ask for it, but the nurse decided he needed estrogen and was injected before he could stop it. The chemical feminization of his body traps him even further in this life of a co-ed.
His mom shows up to help but it is entirely too late.